Muscle Mass Loss With GLP-1 Therapy: Clinical Relevance and Mitigation

glp1 · Lancet Diabetes & Endocrinology · 2025

~25–40% of weight lost on GLP-1 is lean mass — enough to push older adults toward sarcopenia without protein + resistance training.

Authors

Prado CM, Phillips SM, Gonzalez MC, Heymsfield SB

~25–40% of weight lost on GLP-1 is lean mass — enough to push older adults toward sarcopenia without protein + resistance training.