Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

breath · PNAS · 2014

First clinical demonstration that the Wim Hof method (cyclic hyperventilation + cold + mindset) can voluntarily activate the sympathetic nervous system and blunt an inflammatory response to endotoxin.

Authors

Kox M, van Eijk LT, Zwaag J, van den Wildenberg J, Sweep FC, van der Hoeven JG, Pickkers P

Research lens

First clinical demonstration that the Wim Hof method (cyclic hyperventilation + cold + mindset) can voluntarily activate the sympathetic nervous system and blunt an inflammatory response to endotoxin.

  • breath
  • wim hof
  • sympathetic
  • immune
  • inflammation